Empowering Human Performance | Athletigen Blog

Tendon injury and your DNA

Posted by Athletigen on Wed, May 29, 2019
Screen Shot 2019-05-29 at 8.11.20 PMTendons are the tissues that connect your muscles to your bones to help control how your limbs move. They are like thick, strong, elastic bands that function in a manner similar to a spring. In fact, they are so strong you can suspend 12 times your body weight from your Achilles tendon. But tendons are susceptible to injury and our DNA plays a role.

The MMP3 gene is an important factor in keeping your tendons healthy and influencing their growth and repair. Certain variants of this gene are associated with an increased risk of Achilles ‘tendinopathy’, that is, inflammation, pain, and decreased function. This gene may influence tendon injury through a reduced ability to heal and repair following strenuous exercise or trauma.

COL5A1 is involved in the development of type 5 collagen, a key component in the proper development and function of tendons. Variants of this gene may alter how connective tissue responds to mechanical stress and repetitive use.

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